Human Sera
Cayman Chemical 4HydroxyphenylACtylglycIn 50mg
A 5-HT1B receptor agonist selectively binds 5-HT1B over 5-HT1A 5-HT1C 5-HT1D and 5-HT2 (Kis 0 0081 1 5 2 9 1 1 and 7 2 UM respectively) inhibits potassium-induced GABA release from rat globus pallidus slices at 5 4 UM reverses reserpine-induced akinesia in a rat model of Parkinsons disease at 110 and 220 nmol/animal reduces food intake in rats when infused into the pons parabrachial nucleus or the PVN of the hypothalamus (ED50s 1 and 50 nmol respectively) reduces the frequency of pursuits tail rattles threats and attack bites in a resident-intruder test in mice
Cayman Chemical DabrafenIbmesylate 50mg
A bacterial metabolite with diverse biological activities inhibits Streptomyces chitin synthase 1 (IC50 14 Ug/ml) active against C neoformans and R solani (MIC 50 Ug/ml for both) enhances insulin-induced adipocyte differentiation in 3T3-L1 and C3H/10T1/2 cells at 30 and 100 UM
Cayman Chemical Exatecnmesylate 50mg
A typical antipsychotic binds to the dopamine D1 receptor and androgen receptor (Kis 0 01 and 3 UM respectively) an a1-AR antagonist (IC50 4 1 nM in rat forebrain homogenates) an a2-AR antagonist (IC50 2 UM in rat cortical homogenates) inhibits SARS-CoV-2 Mpro activity by 55 at 100 UM increases the number of entries into and the percentage of time spent in the open arms of the elevated plus maze in rats at 0 075 mg/kg
Cayman Chemical 6 7 4-TrIhydroxyIsoflavon 50mg
An active metabolite of disulfiram inhibits liver low Km ALDH in rats (ID50 15 5 mg/kg) decreases MAP and increases heart rate during ethanol challenge in rats at 20 6 mg/kg
Cayman Chemical 3-Deoxy-3-fluorogunosIn 50mg
An active metabolite of bosentan activates the PXR in a reporter assay at 25 UM
Cayman Chemical PIperacetazIn 100mg
A GlcCer synthase inhibitor reduces Gb3 and lyso-Gb3 accumulation in a variety of tissues in the Gla-/- mouse model of Fabry disease reduces the latency to paw withdrawal in the hot plate test in the same model reduces gliosis delays the onset of ataxia and increases lifespan in the transgenic 4LC mouse model of neuronopathic Gaucher disease at 0 03 w/w in the diet
Cayman Chemical MofegIlInhydrochlorIde 50mg
An integrin receptor antagonist binds to aVB3 and aVB5 receptors (Kds 0 69 and 1 UM respectively) in MDA-MB-231 cells inhibits the interaction between aVB5 and human ACE2 or SARS-CoV-2 spike protein in cell-free assays reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 3 16 UM) inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells at 0 1 UM reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model at 1 mg/kg reduces infarct volume and edema in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg
Cayman Chemical 3 3 DIpropylthIdIcarbocnI 50mg
An alkaloid with diverse biological activities inhibits LPS-induced production of NO in primary rat microglia (IC50 13 7 UM) protects against glutamate-induced cytotoxicity in HT22 cells at 100 UM induces relaxation of isolated rat arterial rings precontracted with phenylephrine or potassium chloride reduces reserpine-induced head twitch behavior in mice at 30 mg/kg
Cayman Chemical 6aMethylprednIsoLN 21ACt 100mg
A product of the COX pathway biosynthesized by TXA2 synthase from PGH2 concurrently with TXA2 an agonist of BLT2 in vivo that induces chemotaxis of mast cells
Cayman Chemical AtractylodIn 50mg
Immunogen Peptide from the N-terminal region of human spastin Host Rabbit Species Reactivity ( ) Human Cross Reactivity ( ) Spastin Applications IHC WB
Cayman Chemical -NorepInphrInhydrochlo 100mg
A broad-spectrum cephalosporin antibiotic active against clinical isolates of various Gram-positive and Gram-negative bacteria Salmonella E coli and MRSA (MICs 0 06-0 5 0 015-0 5 and 1-16 Ug/ml respectively) intramammary administration is curative in a bovine model of E coli-induced mastitis at 75 mg/animal
Cayman Chemical 6-MethylpterIn 100mg
A derivative of betulin has been used in the synthesis of a-glucosidase inhibitors
Cayman Chemical LarIxyl Acetate 50mg
An alkyne derivative of betulin can be used for click chemistry applications
Cayman Chemical 5- 3 4-DIhydroxyphenylV 50mg
An analytical reference standard categorized as a quinazolinone intended for research and forensic applications
Cayman Chemical HydrocortIson Aceponate 100mg
An inhibitor of MAO-B selectively inhibits MAO-B by 80 in mouse brain homogenates (ID50 381 nmol/kg) prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice at 29 5-8 47 Umol/kg prevents MPTP-induced lesions in 9- to 10-month-old mice at 0 027 Umol/kg increases the duration of contralateral rotational behavior induced by L-DOPA in a rat model of 6-OHDA-induced Parkinsons disease