Human Sera
Cayman Chemical Betamethason 21phosphatS 100mg
A synthetic glucocorticoid; prevents increases in macrophage and eosinophil numbers in BALF and decreases blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection at 8 mg/kg; inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered topically or subcutaneously at doses of 0.01-1% or 1 mg/kg, respectively; increases maximal lung pressure volume curves in fetal sheep when administered to pregnant ewes at 0.75 gestation at doses of 80 and 170 UG/kg; increases body weight, impairs learning and memory, increases anxiolytic behavior, and reduces hippocampal neurogenesis in CD-1 mice but reduces body weight and increases neurogenesis with no effect on anxiety in high-anxiety DBA/2 mice when administered at a dose of approximately 25 mg/kg per day in the drinking water for seven weeks
Cayman Chemical MethyclothIazIde 50mg
A thiazide diuretic; inhibits norepinephrine- and vasopressin-induced contractions of aortic rings isolated from spontaneously hypertensive rats at a concentration of 100 μM; reduces salt-induced increases in blood pressure in salt-sensitive but not salt-resistant rats without affecting body weight or heart rate
Cayman Chemical AloglIptInbenzoate salt 100mg
An orally bioavailable DPP-4 inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, FAP, and tryptase (IC50s = >100,000 nM); inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma); increases plasma GLP-1 and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats (10 mg/kg); decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days (2.8 mg/kg per day)
Cayman Chemical RhodamIn 101Inr salt 100mg
A bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively
Cayman Chemical N4Benzoyl5O 4 4dImetho 100mg
A building block; has been used in the synthesis of oligodeoxyribonucleotides
Cayman Chemical PF-06651600 100mg
A covalent JAK3 inhibitor (IC50 = 33.1 nM); selective for JAK3 over JAK1, JAK2, and TYK2 (IC50s = >10,000 for all) and a panel of 304 other kinases at 1 µM; inhibits STAT5, STAT6, and STAT3 phosphorylation induced by IL-2, IL-4, or IL-21, respectively, in isolated human lymphocytes (IC50s = 244, 340, and 350 nM, respectively); inhibits T cell differentiation into Th1 and Th17 in a T cell differentiation assay (IC50s = 30 and 167 nM, respectively); reduces paw swelling in a rat model of adjuvant-induced arthritis at 3, 10, or 30 mg/kg; decreases disease severity in a mouse model of EAE when at 30 or 100 mg/kg
Cayman Chemical 2 3 4 5-Tetrachlorophenol 50mg
A metabolite of γ-lindane; toxic to fathead minnows and rainbow trout (LC50s = 0.496 and 0.304 mg/L, respectively, in tank water)
Cayman Chemical VortIoxetIn 50mg
A multimodal serotonergic agent; inhibits 5-HT reuptake (Ki = 1.6 nM); binds to the 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7 receptors (Kis = 15, 33, 3.7, and 19 nM, respectively); binds to the β1-adrenergic receptor (Ki = 46 nM); acts as an antagonist at 5-HT3A and 5-HT7, a partial agonist at 5-HT1B, and a full agonist at 5-HT1A receptors; selective for SERT over the dopamine and norepinephrine transporters (IC50s = 5.3, 890, and 140 nM, respectively); increases 5-HT levels in vivo in rat brain and decreases occupancy at SERT when administered at a dose of 5 or 10 mg/kg per day; has antidepressant-like and anxiolytic-like effects in mice at 5 mg/kg but not 10 mg/kg
Quidel Corporation Normal human serum depleted of complement Factor I protein.
Normal human serum depleted of complement Factor I protein.
Cayman Chemical MethsuxImIde 50mg
An anticonvulsant; inhibits CYP2C19-mediated metabolism of chlorproguanil and proguanil at 100 µM; protects against leptazol-induced convulsions in rats when administered at a dose of 100 mg/kg
Cayman Chemical MethIcIlInsodIum salt 100mg
A semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis; used to study methicillin-resistance in S. aureus
Cayman Chemical nIdulafungIn 50mg
A semisynthetic echinocandin antifungal; inhibits 1,3-β-D glucan synthase from several C. albicans clinical isolates (IC50s = 0.89-7.96 ng/ml for the wild-type enzyme); active against C. albicans, C. parapsilosis, C. tropicalis, and C. guiillermondi (MICs = ≤0.03-4 UG/ml) and A. fumigatus (MIC90 = ≤0.03 UG/ml); increases survival and decreases the severity of pulmonary lesions in A. fumigatus-infected neutropenic rabbits at 10 mg/kg
Cayman Chemical TetrabenazIn 100mg
An inhibitor of VMAT2 that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay); dose-dependently reduces levels of the monoamines norepinephrine, dopamine, and 5-HT in rat brain; has been used to induce depressive-like behavior in animal models; improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal MSNs in a YAC128 transgenic mouse model of Huntington’s disease at 5 mg/kg
Cayman Chemical SKF 38393hydrobromIde 50mg
A partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively)